Knockout studies of the nine identified functional oncogenes showed that knockout of EBF1, IRF4, CARD11, MYD88, and IKBKB is selectively lethal in ABC DLBCL, while knockout ZBTB7A, XPO1, TGFBR2, and PTPN6 is selectively lethal in GCB DLBCL. This evidence concerns the gene IRF4 and diffuse large B-cell lymphoma.