NOTCH2 and diffuse large B-cell lymphoma: In 2020, Stuart et al. analyzed the mutation characteristics of a population-based cohort of 928 DLBCL patients by targeted sequencing of 293 genes and applied Bernoulli mixture-model clustering to classify patients into five molecular subtypes: 1) MYD88, 2) BCL2, 3) SOCS1/SGK1, 4) TET2/SGK1, and 5) NOTCH2, along with a “not elsewhere classified (NEC)” group.