Additionally, several studies discover a reciprocal connection between PrPC and cholesterol metabolism in numerous pathophysiological processes, it is reported that cholesterol transporter ABCA1 affects PrPC concentration by post-translational means in neuroblastoma cells 24, and conversion of PrPC to PrPSC affects cholesterol metabolism of neuronal cells 25, thus PrPC may have a tight interaction with cholesterol metabolism in reproductive system. The gene discussed is PRNP; the disease is neuroblastoma.