Moreover, elevated PrPC promoted proliferative, migratory and invasive abilities of ESC possibly via encouraging cholesterol accumulation and estrogen biosynthesis, and accumulating research has identified that estradiol enhanced invasion of ESC through regulating hsa-circ-0001649 expression 35-37 and cholesterol homeostasis influenced proliferation of bladder cancer cells 38. The gene discussed is PRNP; the disease is urinary bladder carcinoma.