CD44 and hepatocellular carcinoma: It's reported that cholesterol could serve as a ligand of ERRα and favour cellular proliferation and facilitate metastasis behaviour by working on immune cells in breast cancer 26-27, and it hinders invasion and metastasis of hepatocellular carcinoma by means of facilitating CD44 localized in lipid raft 28, which may also matter in EMs, for cholesterol lowering drug pravastatin actually mitigated lesions in mouse models, and multiple undiscovered roles of cholesterol remain to be unearthed.