Studies have confirmed some synergy effects between ferroptosis and current cancer treatments, such as Roh's research 9 found that ferroptosis inducers can work synergistically with cisplatin to suppress the growth of head and neck tumors in mice; Wang's study 10 found that ferroptosis activators and anti-PD-L1 antibody nivolumab synergistically induce melanoma growth inhibition in vitro and in vivo; Moreover, studies have confirmed that ferroptosis inducers enhance radiotherapy sensitivity of melanoma 11, lung cancer and glioma 12-13, breast cancer 14 and nasopharyngeal carcinoma 15. The gene discussed is CD274; the disease is melanoma.