AKT1 and nonpapillary renal cell carcinoma: It was not surprising that PTEN silencing diminished the change in IC50 values of sunitinib, AKT phosphorylation, VCAM-1, CXCL8 and cleaved caspase 3 levels induced by silencing or overexpressing OTUD1 in ccRCC cells (Fig. 6A-F).