OTUD1 and neoplasm: We investigated whether OTUD1 inhibits the tumor growth of ccRCC by inactivating NF-kappa B. We treated 786-O cells with two distinct NF-kappa B inhibitors (IKK-16 and JSH-23) after silencing OTUD1 (Fig. 3L, M) and found that NF-kappa B inhibitors diminished the growth-promoting effect induced by the knockdown of OTUD1 (Fig. 3L, M).