We showed that OTUD1 WT overexpression decreased the IC50 values of sunitinib in both 786-O and ACHN cells (Fig. 5B), but ectopically overexpressed the OTUD1 C320S mutant made little effect on the IC50 values of sunitinib compared to control group (empty vector) in renal cancer cells (Supplementary fig. Here, OTUD1 is linked to renal carcinoma.