In this study, we observed that DCAF8L1 is frequently overexpressed in breast fibroadenomas, benign neoplasms associated with breast cancer 45; it is also expressed in a small proportion of breast cancers; furthermore, expression of DCAF8L1 is induced in naïve hESC H9 cells in which BRCA1 is also downregulated. This evidence concerns the gene BRCA1 and breast cancer.