PTEN and non-small cell lung carcinoma: In contrast to the control group, the protein levels of p-PI3K/PI3K and p-AKT/AKT were upregulated in the hypoxic group and downregulated in the PTEN-L group; in the hypoxic + PTEN-L group, the upregulation of protein levels of p-PI3K/PI3K and p-AKT/AKT can be partially restored by the overexpression of PTEN-L (Figures 3(e), 3(f), p < 0.05, p < 0.01, p < 0.001), which demonstrated that the PI3K/AKT signaling may be participated in the regulation of the reduced PTEN-L secretion caused by hypoxic microenvironment, as well as the PTEN-L-mediated biological behavior of NSCLC cell.