QFG also depressed CRC cell proliferation by the induction of apoptosis through suppressing the PI3K/AKT and ERK signaling pathways, inhibition of the migration of CRC cells by lncRNA ANRIL/let-7a/TGF-β1/Smad Axis, induction of autophagy via mTOR signaling pathway, regulation of tumor angiogenesis of CRC xenograft mice by Sonic Hedgehog pathway, and suppression of lymphangiogenesis via VEGF-C/VEGFR-3-dependent PI3K/AKT pathway [15–19]. Here, AKT1 is linked to neoplasm.