Abnormalities of MAO-B density and/or activity are found in postmortem study of many diseases including Alzheimer’s disease (Saura et al., 1994), Parkinson’s disease (Tong et al., 2017), progressive supranuclear palsy (Tong et al., 2017), multisystem atrophy (Tong et al., 2017), Huntington’s disease (Richards et al., 2011), amyotrophic lateral sclerosis (Ekblom et al., 1993), and alcohol use disorder (Udemgba et al., 2014). This evidence concerns the gene MAOB and early-onset autosomal dominant Alzheimer disease.