Regarding IFN-γ, immunoreactivity was seen in the epithelial lining of the ES in 7 out of 9 ES specimens from patients with MD, whereas strong staining in 4 and moderate staining in 3 were shown in the epithelial cells of ES, although no positive expression of IFN-γ was observed in the epithelial lining of the ES of patients with AN (Figures 5E,F). This evidence concerns the gene IFNG and Menkes disease.