Concerning IL-6, this cytokine exhibited prominent staining along the epithelial lining of the sac, demonstrating a positive expression in 7 out of 9 ES specimens from patients with MD, including epithelial cells immunolabeled strongly (Figure 5C) in 4, moderately in 2 and weakly in 1, whereas a negative expression of IL-6 in all ES specimens of patients with AN was observed (Figure 5D). Here, IL6 is linked to Menkes disease.