The allelic variation in rs4947296, at 6p21.33, developing a nuclear factor-κB (NF-κB)-mediated inflammatory response, are supposed to be related to an abnormal inflammatory response at the ES in bilateral MD (21), and there are higher levels of cytokines/chemokines in patients with MD with high basal levels of IL-1β (42). Here, NFKB1 is linked to Menkes disease.