This study also investigated the functional consequence of elevated adiponectin on immune cells and discovered that adiponectin from the serum of pediatric MS patients led to pro-inflammatory responses in CD14+ monocytes, T-cell activation, upregulation of CNS microglia pro-inflammatory markers, and downregulation of CNS microglial specific quiescent/anti-inflammatory markers (63) all evidence supporting a role of adiponectin to induce disease in children with MS. Here, ADIPOQ is linked to myeloid sarcoma.