Unlike the histopathological features of PSP-RS, which are characterized by neuronal loss, gliosis, and abundant neurofibrillary tangles in the midbrain and SCP (2), the extensive accumulation of tau-immunoreactive inclusions and astrocytic plaques in the gray and white matter is a distinct characteristic of CBD pathology (54). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.