It has already been shown in sporadic and in LRRK2-PD patients that higher serum levels of IL-8, IL-10, MCP-1, MIP-1, TNF-alpha are associated with more severe motor impairment assessed with UPDRS-III, Timed-up and Go and H&Y staging (3, 24, 25). This evidence concerns the gene CCL2 and Parkinson disease.