MTHFR and acute lymphoblastic leukemia: MTHFR, which affects the efficacy and toxicity of antineoplastic drugs such as methotrexate, carboplatin, and cisplatin (level 2A), was more prevalent among our central Han Chinese compared with the other global and East Asian populations (our cohort, VAF = 0.6273, 1KG3.ALL, VAF = 0.2454; G.ALL, VAF = 0.2573; 1KG3.EAS, VAF = 0.2956; G.EAS, VAF = 0.2884).