For example, variant rs4646422, which impairs the function of CYP1A1, was highly prevalent (VAF = 0.2228) in our central Han Chinese population compared with the other populations (1KG3.ALL, VAF = 0.0242; G.ALL, VAF = 0.0077; 1KG3.EAS, VAF = 0.1151; G.EAS, VAF = 0.1535). This evidence concerns the gene CYP1A1 and acute lymphoblastic leukemia.