Although the pathology scores revealed mild endothelial injury, mesangial sclerosis, and interstitial fibrosis in eNOS−/−:VEGFKD (−dox) kidneys, the severity and extension of the changes observed in eNOS−/−:VEGFKD (+dox) kidneys were obvious as demonstrated by highly significant score differences in all parameters. The gene discussed is NOS3; the disease is Diffuse mesangial sclerosis.