NOS3 and diabetes mellitus: Significant tubulo-interstitial damage consisting of tubular atrophy and basement membrane thickening, tubular proteinaceous casts, and interstitial lymphocytic infiltrates were also observed in eNOS−/−:VEGFKD (+dox) (Figures 2B4–6) but were not present in eNOS−/−:VEGFKD (−dox) kidneys (Figure 2A) or in diabetic DM-VEGFKD (+dox) kidneys (Figure 1F).