Podocyte VEGFKD caused renal failure in eNOS−/−:VEGFKD (+dox) mice (Figure 5C, red bar), whereas it did not significantly alter creatinine clearance in mice with diabetes (DM-VEGFKD) or intact eNOS (VEGFKD) (Figure 5C, blue and gray bars, respectively). Here, NOS3 is linked to Renal insufficiency.