NOS3 and diabetic kidney disease: Despite the similar functional consequences of podocyte VEGF-A gain-of-function and knockdown in eNOS−/− mice, their morphologic phenotypes are strikingly different and parallel two histologic variants of DKD described in humans: nodular or diffuse glomerulosclerosis, respectively (Farquhar et al., 1959; Stout et al., 1993).