Short term VEGF-A knockdown in podocytes induces acute renal failure and proteinuria associated with endotheliosis, mesangiolysis, and microaneurisms (Veron et al., 2012), and VEGF-A deletion accelerates DKD in a short term diabetes mouse model (Sivaskandarajah et al., 2012). This evidence concerns the gene VEGFA and acute kidney injury.