NOS3 and diabetes mellitus: In contrast, eNOS−/−:VEGFKD mice with podocyte VEGFKD (+dox) revealed extensive foot process effacement, GBM thickening, severe mesangial sclerosis, and endotheliosis (Figures 3G,H), a more severe phenotype than that observed in diabetic DM-VEGFKD (+dox) kidneys (Figures 3C,D).