eNOS KO mice are susceptible to developing renal failure in the setting of diabetes (Zhao et al., 2006; Nakagawa et al., 2007; Hudkins et al., 2010; Kakoki et al., 2010; Alpers and Hudkins, 2011; Yuen et al., 2012; Takahashi and Harris, 2014), reduced renal mass (Nakayama et al., 2009), and VEGF-A gain-of-function (Veron et al., 2014). This evidence concerns the gene NOS3 and kidney failure.