While A and T are considered specific of AD, neuropathological (N) biomarkers [e.g., cerebrospinal fluid (CSF) total tau, FDG PET hypometabolism, and atrophy on MRI] are considered non-specific indicators of damage for AD which may derive from a variety of etiologies (Jack et al., 2016, 2018). This evidence concerns the gene MAPT and Alzheimer disease.