MAPT and Cognitive impairment: Previous investigations conducted in non-demented adults demonstrated that positivity in phosphorylated tau (T +) drives cognitive dysfunction, especially in the memory domain (Ingala et al., 2021), although there is also evidence that cognitive deficits in episodic memory, executive function, and global cognitive function are positively associated with amyloid burden in adults without a diagnosis of MCI or AD dementia (Hedden et al., 2013).