Though the impact of GABAergic inhibitory functions of PFC CRH+ interneurons on affect regulation and stress response remains unexplored, reduced inhibitory function of CRH+ interneurons is consistent with previous observations of preferential disruption of GABA-related genes compared to excitatory-related genes in MDD (9, 22, 24, 58–60). Here, CRH is linked to major depressive disorder.