The mean TMB in KRAS-mutant CRC was 10.8 mut/Mb (median = 5.0), whereas that in BRAF-mutant CRC and double-mutant CRC was 24.7 mut/Mb (median = 8.2 mut/Mb) and 59.4 mut/Mb (median = 36.1), respectively. The gene discussed is BRAF; the disease is colorectal carcinoma.