The homeostasis model assessment estimate of insulin resistance (Homa-IR) [(fasting glucose × fasting insulin)/22.5] [26], the Matsuda index of insulin sensitivity (ISI-Matsuda) [10,000/glucose (mg/dL) × insulin (mU/mL) × glucose mean × insulin mean] [27], the oral disposition index (DIo) [(ΔInsulin 0–30/ΔGlucose 0–30) × (1/fasting insulin)] [28] and the area under the curve for insulin (AUC2h insulinemia) and glucose (AUC2h glycaemia) were calculated. The gene discussed is INS; the disease is Insulin resistance.