S100A8 and malignant colon neoplasm: Other reports have indicated that S100 protein can increase Wnt signaling; for example, the role of S100A8 is partially dependent on the activation of Wnt/β-catenin signaling, and inhibition of S100A4 expression impedes colon cancer progression caused by the Wnt/β-catenin signaling pathway [41, 42].