S100A16 and acute kidney injury: To further investigate the role of S100A16 in AKI linked to Wnt/β-catenin signaling, rat renal interstitial fibroblasts (NRK-49F cells) were cultured under basal or hypoxic conditions, with or without different concentrations (0, 5, and 10 μM) of ICG-001, a Wnt/β-catenin signaling pathway inhibitor.