The results of our study have indicated that the incidence of postoperative delirium in patients with hip fracture is 13.06%, and age ≥ 75 years, BMI ≥ 24 kg/m2, history of delirium, estimated blood loss ≥ 400 mL, duration of surgery ≥ 120 min, preoperative albumin ≤ 40 g/L and TSH ≤ 2 mU/L are the independent risk factors of postoperative delirium in patients with hip fracture. This evidence concerns the gene ALB and delirium.