For example, prostate-specific antigen (PSA) screening for average-risk men [6, 7], lung cancer screening for asymptomatic patients [8], and axillary staging and post-lumpectomy radiotherapy in women older than 70 years of age with clinically node-negative, hormone receptor + breast cancer [9] are considered low-value services in cancer care delivery. Here, KLK3 is linked to cancer.