GJA1 and intervertebral disk degenerative disorder: Our results similarly showed that miR-206 was downregulated in IDD tissues, miR-206 overexpression could improve LPS-induced NP cell injury in vitro, and upregulation of GJA1 could reverse the effect of miR-206 on LPS-induced NP cells, indicating that miR-206/GJA1 axis was involved in regulating progression of IDD.