Yeste et al. engineered NPs to deliver β cell antigen proinsulin combined with a tolerogenic molecule, the aryl hydrocarbon receptor (AhR) ligand 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) in a mouse model of type 1 diabetes [110]. This evidence concerns the gene INS and type 1 diabetes mellitus.