CCR2 and atherosclerosis: Wu et al. developed a CCR2 short hairpin (shRNA)-loaded EGFP-EGF1-conjugated poly (lactic-co-glycolic acid) (PLGA) nanoparticles (ENPs) to selectively knock down the expression of CCR2 in atherosclerotic cellular models of macrophages, which becomes a potential tool for modulating macrophage-related inflammation in atherosclerosis [38].