Interestingly, SIRT5-KO cells migrated significantly faster than PC-3 cells as measured by TScratch software (P < 0.001), and increased in migration was also observed in PC-3 cells treated with SIRT5 inhibitors (Figure 1B; Figure S1D), suggesting that SIRT5 regulates the migration of PCa cells. This evidence concerns the gene SIRT5 and posterior cortical atrophy.