When combined with genetically-influenced lower LDL-C levels, genetically-influenced lower TG via APOA5 were associated with the same CAD risk as the genetically lower TG via LPL (OR (95% CI):(0.83 (0.79;0.86) vs. 0.83 (0.80;0.86), respectively). Here, APOA5 is linked to coronary artery disorder.