SIK2 and ovarian carcinoma: Interestingly, we found that ovarian cancer cells with SIK2 knockdown had increased cell area (P = 0.0025 for SKOV3, Fig. 1E and P = 0.0015 for OVCAR8, Fig. S1C), while cells with SIK2 overexpression exhibited reduced cell area (P = 0.005 for SKOV3, Fig. 1F), indicating a contractile phenotype.