SIK2 has been shown to play an important role in various biological processes, including gluconeogenesis, neuronal survival, melanogenesis, hepatic steatosis, centrosome splitting, reprogramming of glucose metabolism, as well as fatty acid, cholesterol syntheses and paclitaxel chemosensitivity [23, 24, 25, 26, 27]. This evidence concerns the gene SIK2 and steatosis.