These 8 tumors were also lowly infiltrated by efficient T cells, defined by CD8-positive PD1-negative cells [median at 15.3 per mm2; range (0.1-137.7) and none contained any TLS; only one tumor had a weak PD-L1 expression on tumor cells (no. 7) (Fig. 2c, d). This evidence concerns the gene PDCD1 and neoplasm.