CD274 and neoplasm: TLS are ectopic lymphoid formations structured with a T-cell zone with mature dendritic cells, a germinal center with proliferating B cells and are the lymphoid organs closest to the tumor generating an adaptative immune response.17-19 Other biomarkers of response to ICI, also described in STS, include higher densities of cytotoxic tumor-infiltrating T cells, activated T cells, and an increased percentage of tumor-associated macrophages expressing PD1 ligand 1 (PD-L1).20