The results revealed that the expression of ZC3H13 in HCC patients was significantly and positively correlated with four types of immune cell infiltration, including CD4+ T cells (P = 2.32E-07), macrophages (P = 2.96E-03), neutrophils (P = 1.51E-09) and dendritic cells (P = 1.07E-03). This evidence concerns the gene ZC3H13 and hepatocellular carcinoma.