To test our hypothesis, we studied the role of HNRNPC, RhoA, ROCK2, YAP and TAZ in PC tumour and paired adjacent normal tissues and the human PC cell lines BxPC‐3 and Panc‐1 using cell viability, qRT‐PCR, Western blotting, DNA damage repair and fragmentation, RNA immunoprecipitation and immunohistochemistry assays. This evidence concerns the gene HNRNPC and pachyonychia congenita.