In one of the first mechanistic studies in this field, induction of tissue inhibitor of metalloproteinase-1 (TIMP-1) expression was shown to be a cause of the anti-invasive effect of THC, Met-AEA and CBD in cervical and lung cancer cells, with cannabinoid receptors (THC, Met-AEA, CBD) and TRPV1 (Met-AEA, CBD) mediating this response [89, 90]. The gene discussed is TRPV1; the disease is lung cancer.