RUNX1 and central nervous system cancer: In glioma stem cells, a cell subpopulation of glioblastoma multiforme implicated in chemoresistance, CBD was further shown to induce a TRPV2-dependent autophagic process that stimulates glioma stem cell differentiation via induction of a splice variant of the acute myeloid leukaemia transcription factor (Aml-1), thereby abrogating their chemoresistance to carmustine [83].