Finally, further work showed that JZL184 impairs bone metastasis of osteotropic prostate and breast cancer cells in mice and inhibits metastasis of osteosarcoma cells [115] and that knockdown of MAGL is associated with reduced lymph node metastasis in MAGL-overexpressing nasopharygeal carcinoma cells [116]. This evidence concerns the gene MGLL and osteosarcoma.