CNR2 and hepatocellular carcinoma: In support of the importance of modulation of extracellular matrix proteolysis in anti-invasive cannabinoid action, other groups have demonstrated downregulation of MMP-2 by THC in glioma cells [94] and downregulation of MMP-2 and -9 in HCC cells treated with CB1 (ACEA) or CB2 agonists (CB65) [95].