Another recent study investigating the in vitro effects of CBD on human gastric cancer cells revealed an antiproliferative effect accompanied by significant upregulation of ataxia telangiectasia mutated (ATM) gene and p21 protein expression and downregulation of p53 protein expression, which subsequently resulted in decreased levels of CDK2 and CCNE and cell cycle arrest in the G0/G1 phase [53]. This evidence concerns the gene ATM and gastric cancer.