CNR2 and lung carcinoma: While studies with selective CB2 agonists [95, 102] as well as inhibitor studies [36, 89, 90, 93, 103] suggest a role for CB2 in the anti-invasive effects of various cannabinoids, a recent investigation reported that silencing of the CB2 receptor reduced proliferation, migration and invasion of lung cancer cells, which was associated with reduced levels of phospho-Akt, phospho-mTOR and decreased expression of 70-kDa ribosomal protein S6 kinase (p70S6K), a mitogen-activated Ser/Thr protein kinase that promotes cell survival and growth [106].