MAP1LC3A and leukemia: Finally, recent evidence suggests that CBD at a relatively high concentration of 30 μM switches the mitochondrial voltage-dependent anion channel (VDAC) from fully open to major subconductance state, thereby arresting the Ca2+-permeable state of this channel and inducing a severe oxidative stress, mitochondrial Ca2+ overload, Cyt c release into the cytosol as well as induction of LC3-phosphatidylethanolamine conjugate (LC3-II) and caspase activation in leukaemia cells [78].