M2 polarisation also proved to be the mechanism by which the CB2 agonist JHW-133 attenuated its own tumour-regressive effect in nude mice with intracranial glioma xenografts, which was only fully expressed by knockdown of cytochrome P450 2J2 (CYP2J2), which mediates the proangiogenic effect [140]. Here, CNR2 is linked to central nervous system cancer.