TRPV1 and lung carcinoma: In another investigation, siRNA, inhibitor and add-back experiments showed that the cannabinoid receptor- and TRPV1-dependent downregulation of plasminogen activator inhibitor (PAI)-1 in CBD-exposed lung cancer cells [103] is part of the anti-invasive effect of this cannabinoid, in addition to the upregulation of TIMP-1 mentioned above.