For other peripheral cells, such as neutrophil granulocytes, their ability to produce proangiogenic factors such as VEGF after exposure to LPS was shown to be blocked by treatment with CB1 (ACEA) and CB2 agonists (JWH-133), which in turn led to decreased tumour growth via inhibition of angiogenesis [125]. The gene discussed is CNR2; the disease is neoplasm.