It was showed that the expression of CTSB in IDH wide-type (Fig. 1C,D overall grade; E, F low-grade gliomas (LGG); G, H HGG), 1p19q non-codeletion type (Fig. 1I,J) and MGMT promoter unmethylation type (Fig. 1K,L) were significantly higher than those in IDH mutant-type (especially for HGG), 1p19q codeletion type and MGMT promoter methylation type of gliomas respectively. The gene discussed is CTSB; the disease is central nervous system cancer.