MGMT and central nervous system cancer: Secondly, we further explored the role that CTSB played in the prognosis of gliomas together with other factors such as gender, age, WHO grade, IDH mutant status, MGMT promoter methylation type and 1p19q codeletion status (Fig. 3A,B overall grade; Fig. S2A, B LGG; Fig. S2C, D HGG).