GUCY1A2 and hypertensive disorder: We observed that IGF2 gene is associated with 120 diseases including Cardiovascular Diseases, Colorectal Neoplasms, Cardiomyopathies, Liver carcinoma, Anemia; the CXCL2 gene is associated with 19 diseases including rheumatoid arthritis, heart failure, hypertensive disease, IBN inflammation, pulmonary fibrosis, acute lung injury while the ZFP36, KLF6, GUCY1A2 and PAG1 was linked with 18 diseases including liver cirrhosis, experimental prostatic neoplasms, stomach carcinoma, inflammation, arthritis, especially which could be a severe comorbidities of the COVID-19 patients.