Moreover, we show that during infection with P. aeruginosa and in response to T3SS, CrkII isoform of Crk adaptor protein interacts with Abl tyrosine kinase and this interaction is required for Abl kinase autophosphorylation (transactivation) and for the subsequent phosphorylation cascade through Abl → PKCδ → NLRC4, and ultimately for NLRC4 inflammasome assembly and activity. The gene discussed is CRK; the disease is infection.