MYC and malignant colon neoplasm: This involves oncogenic SE-mediated tethering of active MYC alleles to nuclear pores to increase transcript export into the cytoplasm and help transcripts escape the nuclear degradation system in colon cancer cells; in this process, AHCTF1 connects nucleoporins to the OSE via the β-catenin-TCF4 complex (Fig. 2b).