Although a recent study suggests that poly(I:C)-induced arthritis is regulated by the TLR3-p38 MAPK-NF-κB Il-33 pathway, which is modulated by the p65 and peroxisome proliferator-activated receptor-γ (PPARγ) complex, the role of TLR3 activation in the pathogenesis of osteoarthritis remains elusive [16]. The gene discussed is TLR3; the disease is osteoarthritis.