CXCL8 and escherichia coli infection: The genes in the ULB with specific high RPS were related not only to basic cellular functions (e.g., ‘negative regulation of peptidyl-serine phosphorylation’ and ‘regulation of chromatin organization’) but also to disease and immune responses (e.g., ‘regulation of necrotic cell death’, ‘pathogenic Escherichia coli infection’, ‘regulation of viral process’) (Additional file 3: Fig. S5b); one example of such a gene is CXCL8 (also known as IL-8) [39] (Fig. 7c).