GBA2 and neurodegenerative disease: Therefore, through the neurons analysis (Additional file 8), “interferon signaling” and “RIG-I-like receptor signaling” have been the top-scored Reactome 2016 and KEGG 2019 pathways respectively, suggesting that neuroinflammation might play an important role in the pathogenesis of SA similarly to other neurodegenerative diseases, such as AD [83], FRDA [84, 85] and ALS [86, 87] or it may even be the reaction of the cells to the altered function of GBA2.