HAND2 and colorectal carcinoma: The identified MES-specific CRC consists of 20 TFs, including PRRX1 and SNAI2, TWIST1, TWIST2, NOTCH2, NOTCH3, and MAML2, while the ADRN CRC includes 18 TFs, among which PHOX2A, PHOX2B, HAND1, HAND2, ASCL1, GATA2, GATA3, and DBH and TH enzymes for catecholamine biosynthesis, all involved in the specification of the sympathetic nervous system [31].