HAND2 and neuroblastoma: It also emerged that ASCL1 binds to the associated enhancers and regulates the expression of the ADRN neuroblastoma CRC members PHOX2B, HAND2, GATA3, TBX2, and ISL [32, 75, 104], in concert with LMO1 and MYCN, and it is necessary for NB cell growth and arrest of differentiation [107].