Moreover, deregulation of gene expression, especially overexpression of MYCN [4, 21–24], ALK [10–13], PHOX2B [25, 26], and LIN28B [27, 28], play a key role in initiation and progression of NB by altering the balance between cell proliferation and differentiation [16, 29–31]. Here, PHOX2B is linked to neuroblastoma.