Remarkably, MARCH11, NPY, EBF1, HAND2, ALK, CCND1 and EXOC4 genes, all involved in enhancer hijacking events in NB, showed the highest expression in neuroblast trajectory cells, suggesting that the neuroblast lineage is specifically at risk of acquiring genetic alterations promoting neuroblastoma formation [44]. The gene discussed is HAND2; the disease is neuroblastoma.