The identified ADRN-specific CRC includes important TFs like MYCN, PHOX2A, PHOX2B, ASCL1, HAND2, GATA2, GATA3, MEIS2, LMO1, TBX2, ISL1 and the tyrosine kinase receptor ALK, and DBH and TH enzymes involved in the metabolism of catecholamines. This evidence concerns the gene GATA3 and colorectal carcinoma.