Moreover, the knockdown effect of these master regulators correlated with the corresponding MES or ADRN TF activity, therefore MES cells resulted more sensitive to the knockdown of MES-specific CRC TFs, such as NFKB2, RUNX1, and RARB, and ADRN cells were more sensitive to the knockdown of adrenergic master regulators, such as PHOX2B, HAND2, and GATA3. These results support the notion that cell survival in the epigenetic subtypes is dependent on subtype-specific CRC networks [87]. The gene discussed is HAND2; the disease is colorectal carcinoma.