ISL1 and colorectal carcinoma: The identified ADRN-specific CRC includes important TFs like MYCN, PHOX2A, PHOX2B, ASCL1, HAND2, GATA2, GATA3, MEIS2, LMO1, TBX2, ISL1 and the tyrosine kinase receptor ALK, and DBH and TH enzymes involved in the metabolism of catecholamines.