The MES-specific CRC includes the TFs PRRX1, TWIST1, SNAI2, MAML3, RUNX1, NFKB, AP-1 family members (JUN and FOS) and the retinoic acid receptor beta, RARB [32, 33, 75, 87, 107] (Fig. 4). Here, SNAI2 is linked to colorectal carcinoma.