Besides the main subtype-specific modules, the authors identified highly specific CRC TF subtype modules such as the MYCN subtype including MYCN, TWIST1, SOX11, and TBX2 and the ADRN MNA-LR module including ZNF423, FOXO3, MEIS2, and CREB5. This evidence concerns the gene MEIS2 and colorectal carcinoma.