This characterization conducted by mRNA profiling and ChIP-seq analysis of H3K27ac, a well characterized marker for active enhancers [93], led to the discovery of two SE-associated TF networks that epigenetically define and shape the MES and the ADRN cell identities and the intra-tumoral heterogeneity and control the gene expression program of NB [32]. This evidence concerns the gene TF and neuroblastoma.