Moreover, we selected the regular hepatic cell line (HL-7702) and HCC cell lines (Huh-7, HCC-LM3, MHCC-97H, SMMC-7721) to perform RT-qPCR, revealing the expression of circ-ZEB1 and PIK3CA in liver cancer cell lines(Fig. 1G and H). Here, PIK3CA is linked to hepatocellular carcinoma.