Results showed that serum EV-derived ARG 1 levels were significantly associated with T2DM, especially in the subgroup of T2DM for more than 10 years (OR 1.651, 95% CI = 1.066–2.557; P value, 0.025), after adjustment for age, sex, BMI, smoking and drinking history, SBP, LDL-C, HDL-C, TG, hs-CRP, and the comorbidities of coronary heart disease. This evidence concerns the gene CRP and type 2 diabetes mellitus.