NLRP3 and gastric ulcer: 2015; Fu et al. 2018; Luo et al. 2018). The up-regulation of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-α) and interleukins factors (IL‐1β and IL‐6), was observed in the acute phase of gastric ulceration (Hernández et al. 2014; Li Q et al. 2018). The nuclear translocation of nuclear factor-κB (NF-κB) P65 plays an essential role in the increment of TNF-α and interleukin-6 (IL-6), as well as NACHT, LRR and PYD domains containing protein 3 (NLRP3) inflammasome, which regulates the synthesis of interleukin-1β (IL-1β) (Doyle and O'Neill 2006; Zhen and Zhang 2019).