Our findings suggest that SV exerts pleiotropic effects, associated with negative modulation of lipid accumulation and peroxidation, ALE-RAGE pathway, oxidative stress, and iNOS expression, protects microcirculatory dysfunction associated with NAFLD, and recovers tissue perfusion, thereby contributing to the repositioning of statins for NAFLD treatment. The gene discussed is NOS2; the disease is metabolic dysfunction-associated steatotic liver disease.