Activated PSCs promote β-cell apoptosis or transdifferentiation into α-cells, generating glucose intolerance [6] and they exhibit a high capacity to express growth factors (transforming growth factor-beta (TGFβ) and vascular endothelial growth factor (VEGF)), proinflammatory cytokines (TNFα, IL6, IL8 and IL10) and autocrine factors (cyclooxygenase-2 (Cox2), Collagen 1, activin A and inducible nitric oxide synthase (iNOS)) [3,5]. Here, NOS2 is linked to Glucose intolerance.