This is because of the limited data, such as only measuring serum adiponectin focused on obesity and gluconeogenesis without evaluation of hepatic fibrosis in mice fed a high-fat diet and AO extract for eight weeks [11], and evaluating the activation of FXR by AO extract in α-naphthylisothiocyanate-induced cholestasis in rat models and not NAFLD rodents [12]. Here, NR1H4 is linked to obesity due to melanocortin 4 receptor deficiency.