Experimental evidence confirmed that biomarkers of endothelial dysfunction, such as intercellular adhesion molecule 1 (ICAM-1), are increased in AD; endothelial cells, astrocytes and microglia show enhanced levels of ICAM-1 in pathological states, and this plays a role in neuritic plaques on neurite growth and neurodegeneration [145,146,147]. The gene discussed is ICAM1; the disease is Alzheimer disease.