Chronic kidney disease (CKD) is characterized by persistent urine anomalies and a gradual loss in kidney structure and function (e.g., a glomerular filtration rate <60 mL/min/1.73 m2 and/or albumin levels ≥30 mg per 24 h) for more than 3 months, and tubulointerstitial fibrosis is the hallmark of CKD regardless of its etiology [118,119,120]. This evidence concerns the gene ALB and chronic kidney disease.