In atherosclerosis, IL-17 and TNF-α synergistically activate NF-κB signaling and mitogen-activated protein kinases to induce neutrophil-attracting chemokines and other inflammation modulators, and increase aortic inflammation and thrombosis, eventually exacerbating cardiovascular diseases and increasing the morbidity associated with them [31]. Here, NFKB1 is linked to atherosclerosis.