For example, in an observational study in Iran involving 442 patients in general wards and 66 patients in the ICU, of whom 55 died, only age (p < 0.001, albumin (p < 0.001), calcium, (p = 0.002) and serum 25(OH)D (p = 0.047)) were significantly associated with mortality in multivariate analysis, whereas BMI, diabetes mellitus, hypertension, IHD, creatinine, and phosphorus were not [86]. The gene discussed is ALB; the disease is hypertensive disorder.