In addition to IgE-mediated cow’s milk allergy, a substantial part of the children has non-IgE-mediated CMA, resulting in delayed-type reactions (>2 h) lacking the typical IgE-mediated symptoms (urticaria, angioedema, respiratory and/or gastro-intestinal symptoms or anaphylaxis) [1,13,14]. The gene discussed is IGHE; the disease is anaphylaxis.