Obesity is associated with adipocyte dysfunction resulting in the alteration of normal physiology of adipocytes leading to increased production of proinflammatory cytokines and decreased production of adiponectin, increased synthesis of CRP, and increased lipolysis, which results in the activation of the signaling pathways such as inhibitor of nuclear factor kappa-B kinase subunit beta (IKK-β) and NF-κβ leading to low-grade inflammation. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.